RNDr. Tomáš Etrych, DSc.

Head of Research Programme: Biomaterials and Tissue Engineering

etrych@imc.cas.cz

+420325873804, +420325873806

At the Department of Biomedical Polymers of the Institute of Macromolecular Chemistry CAS, Dr. Etrych has long been researching new water-soluble macromolecules which are, due to their specific properties, suitable for use in medicine.

These macromolecules can be used as drug carriers that allow transport and subsequent site-specific activation (e.g. in the tumor) of the attached low-molecular-weight drug. Due to their higher molar mass, these macromolecules can significantly prolong the circulation time of the biologically active substance. These positive properties can be utilized in the treatment of both chronic and acute diseases. Recently, the similar macromolecular systems have been intensively studied as potential gene delivery carriers or so-called polymer vaccines. In this specific case, the polymer platform can serve as a carrier for a long-circulating vaccine system.

Recent publications

2018

Chytil P., Koziolová E., Etrych T., Ulbrich K. HPMA copolymer-drug conjugates with controlled tumor-specific drug release Macromolecular Bioscience. Roč. 18, č. 1 (2018), s. 1700209_1-1700209_15

Zaborova O., Filippov S., Chytil P., Kováčik L., Ulbrich K., Yaroslavov a. A., Etrych T. A novel approach to increase the stability of liposomal containers via in prep coating by poly[n-(2-hydroxypropyl)methacrylamide] with covalently attached cholesterol groups Macromolecular Chemistry and Physics. Roč. 2018, 2018, č. 1700508_1-1700508_5

Islam W., Fang J., Etrych T., Chytil P., Ulbrich K., Sakoguchi A., Kusakabe K., Maeda H. HPMA copolymer conjugate with pirarubicin: in vitro and ex vivo stability and drug release study International Journal of Pharmaceutics. Roč. 536, č. 1 (2018), s. 108-115

W. Islam, J. Fang, T.Etrych, P. Chytil, K. Ulbrich, A.Sakoguchi,K. Kusakabeb, H. Maeda, HPMA copolymer conjugate with pirarubicin: In vitro and ex vivo stability and drug release study, International Journal of Pharmaceutics 536 (2018) 108-118

Islam W., Fang J., Etrych T., Chytil P., Ulbrich K., Sakoguchi A., Kusakabe K., Maeda H. HPMA copolymer conjugate with pirarubicin: in vitro and ex vivo stability and drug release study International Journal of Pharmaceutics. Roč. 536, č. 1 (2018), s. 108-115.

2017

Koziolová E., Chytil P., Etrych T., Janoušková O. Ability of polymer bound P-glycoprotein inhibitor ritonavir to overcome multidrug resistance in various resistant neuroblastoma cell lines Anti-Cancer Drugs. Roč. 28, č. 10 (2017), s. 1126-1130

Šírová M., Strohalm J., Chytil P., Lidický O., Říhová B., Etrych T. The structure of polymer carriers controls the efficacy of the experimental combination treatment of tumors with HPMA copolymer conjugates carrying doxorubicin and docetaxel Journal of Controlled Release. Roč. 246, 2017, s. 1-11

Koziolová E., Goel S., Chytil P., Janoušková O., Barnhart t. E., Cai W., Etrych T. A tumor-targeted polymer theranostics platform for positron emission tomography and fluorescence imaging Nanoscale. Roč. 9, č. 30 (2017), s. 10906-10918

M. Šírová, J. Strohalm, P. Chytil, O. Lidický, B. Říhová, T. Etrych, The structure of polymer carrier controls efficacy of combination treatment of experimental tumors with HPMA copolymer conjugates carrying doxorubicin and docetaxel, Journal of Controlled Release 246, (2017) 1-11.

2015

Chytil P., Koziolová E., Janoušková O., Kostka L., Ulbrich K., Etrych T. Synthesis and properties of star HPMA copolymer nanocarriers synthesised by RAFT polymerisation designed for selective anticancer drug delivery and imaging Macromolecular Bioscience. Roč. 15, č. 6 (2015), s. 839-850

Etrych T, Strohalm J, Sirova M, Tomalova B, Rossmann P, Rihova B, Ulbrich K, and Kovar M. High-molecular weight star conjugates containing docetaxel with high anti-tumor activity and low systemic toxicity in vivo. Polym. Chem. 2015, 6, 160-170.

2013

Sirova M, Kabesova M, Kovar L, Etrych T, Strohalm J, Ulbrich K, Rihova B. HPMA copolymer-bound doxorubicin induces immunogenic tumor cell death. Curr Med Chem. 2013;20(38):4815-26.

2012

Hofman S., Vystrčilová L., Ulbrich K., Etrych T., Caysa H., Müller T., Mäder K., Dual Fluorescent HPMA Copolymers for Passive Tumour Targeting with pH-Sensitive Drug Release: Synthesis and Characterisation of Distribution and Tumour Accumulation in Mice by Noninvasive Multispectral Optical Imaging, Biomacromolecules 13 (2012) 652-663

Chytil P., Etrych T., Ulbrich K., Hydrolytically Degradable Polymer Micelles for Anticancer Drug Delivery to Solid Tumours, Macromolecular chemistry and physics 213 (2012) 858-867

Etrych T, Subr V, Strohalm J, Sírová M, Ríhová B, Ulbrich K. HPMA copolymer-doxorubicin conjugates: The effects of molecular weight and architecture on biodistribution and in vivo activity. J Control Release. 2012 Dec 28;164(3):346-54.

2011

Etrych T., Kovář L., Strohalm J., Chytil P., Říhová B., Ulbrich K., Biodegradable star HPMA polymer-drug conjugates: biodegradability, distribution and anti-tumour efficacy, J. Controlled Release 154, 241-248 (2011)

Etrych T., Kovář L., Strohalm J., Chytil P., Říhová B., Ulbrich K., Biodegradable star HPMA polymer-drug conjugates: biodegradability, distribution and anti-tumour efficacy, J. Controlled Release 154, 241-248 (2011).

2010

Etrych T., Šírová M., Starovoytova L., Říhová B., Ulbrich K., HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release, Mol. Pharmaceutics. 7 (NO. 4), 1015–1026 (2010)

Etrych T., Šírová M., Starovoytova L., Říhová B., Ulbrich K., HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release, Mol. Pharmaceutics. 7 (NO. 4), 1015–1026 (2010).