Opportunity for students: Investigate the Role of ABCF Proteins in Translation and Antibiotic Resistance
Join the Antibiotic Research Group at BIOCEV Research Center. The Antibiotic Resistance Research Group at the BIOCEV center is offering a diploma project for dedicated students, which will contribute to research of ABCF proteins and their impact on translation and antibiotic resistance.
Project Scope: Investigation of the biological function and molecular mechanisms of ABCF proteins in antibiotic-producing filamentous bacteria of the genus Streptomyces sp.
Understanding ABCF Proteins: The diploma project will focuse on investigating the biological function and molecular mechanisms of ABCF proteins in antibiotic-producing bacteria of the genus Streptomyces sp. ABCF ATPases are translational factors that play an important role in Streptomyces in regulating antibiotic production and response to translational stress, including protection of the ribosome from antibiotics. Most of the 30 bacterial ABCF subfamilies are still unexplored, providing an exciting opportunity for discovery.
Our laboratory employs a range of methodological approaches, including genetic manipulations (DNA cloning, site-directed mutagenesis, CRISPR genome editing), cell-free transcription-translation assays, heterologous expression and purification of proteins, ribosome profiling or teoprinting.
Application Process: Interested applicants are invited to email Dr. Gabriela Balíková Novotná at gnovotna@biomed.cas.cz